GBF1

Across TCGA pan-cancer cohorts, GBF1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GBF1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GBF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GBF1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where GBF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.698	1.000	.004	25	view →
HNSC	OS	Quartile	All	0.966	0.874	.014	22	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
CCRCC	DFS	Quartile	III,IV	0.246	0.787	<.001	6	view →
UCEC	DFS	Tertile	All	0.945	0.838	.024	6	view →
GBM	OS	Median	All	0.637	0.406	.044	2	view →
LSCC	DFS	Median	All	0.823	0.504	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GBF1–LUAD (DFS)

Open the LUAD breakdown →