GBF1

Across TCGA patient cohorts, GBF1 mutation is significantly associated with the RNA expression of many other genes, with 3,130 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBF1-associated genes across cancer lineages are LINC02629, RN7SL134P, and CDCA2. Each is linked with GBF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GBF1-to-partner and partner-to-GBF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02629 grouped by GBF1-low versus GBF1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBF1→partner) and Y-score (partner→GBF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	LINC02629 →	+0.056	+4.653	.005	.007	3	3
READ	RN7SL134P →	+0.257	+5.179	<.001	.001	3	3
UCEC	CDCA2 →	+0.710	+1.632	<.001	<.001	3	3
UCEC	SKA1 →	+0.741	+2.055	<.001	<.001	3	3
UCEC	POLR3K →	+0.322	+1.906	.004	.001	3	3
UCEC	PBK →	+0.831	+1.642	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,130 associations by consensus.

LINC02629 by GBF1 expression — READ

Explore this box plot interactively →