GBF1

Across TCGA cell cohorts, GBF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,387 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GBF1-associated GO terms across cancer lineages are Protein localization to endoplasmic reticulum exit site, COPI-coated vesicle budding, and Golgi transport vesicle coating. Each is linked with GBF1 in more than 19 cancer types. Because this analysis shows association rather than direction, both GBF1-to-partner and partner-to-GBF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to endoplasmic reticulum exit site grouped by GBF1-low versus GBF1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GBF1→partner) and Y-score (partner→GBF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Protein localization to endoplasmic reticulum exit site →	+0.174	+1.046	<.001	<.001	3	20
KIDNEY	COPI-coated vesicle budding →	+0.123	+0.759	<.001	<.001	3	19
KIDNEY	Golgi transport vesicle coating →	+0.123	+0.759	<.001	<.001	3	19
KIDNEY	COPI coating of Golgi vesicle →	+0.123	+0.759	<.001	<.001	3	19
OESOPHAGUS	Cytosolic transport →	+0.088	+0.996	<.001	.001	3	17
BONE	Golgi disassembly →	+0.143	+0.884	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,387 associations by consensus.

Protein localization to endoplasmic reticulum exit site by GBF1 expression — PANCREAS

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