GBF1

Across TCGA cell cohorts, GBF1 mutation is significantly associated with the RNA expression of many other genes, with 1,099 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GBF1-associated genes across cancer lineages are WFDC13, ABCG4, and PRSS55. Each is linked with GBF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBF1-to-partner and partner-to-GBF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC13 grouped by GBF1-low versus GBF1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBF1→partner) and Y-score (partner→GBF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	WFDC13 →	+0.259	+3.622	<.001	.003	3	2
LARGE_INTESTINE	ABCG4 →	+0.214	+1.741	<.001	.003	3	2
SKIN	PRSS55 →	+0.151	+4.467	<.001	.004	3	2
LUNG_SCLC	OR10AG1 →	+0.128	+4.523	<.001	.003	3	1
BLOOD_Leukemia	VWC2 →	+0.379	+3.551	<.001	.009	3	1
BLOOD_Leukemia	GPX6 →	+0.062	+3.551	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,099 associations by consensus.

WFDC13 by GBF1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →