GBE1

Across TCGA pan-cancer cohorts, GBE1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GBE1 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GBE1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GBE1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, LUAD, and COAD are the cancer types where GBE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.273	0.486	<.001	68	view →
LUAD	OS	Quartile	II,III,IV	0.311	0.793	.001	31	view →
COAD	DFS	Median	All	0.887	1.000	.022	12	view →
HNSC	DFS	Tertile	IV	0.854	0.545	.008	5	view →
LSCC	OS	Median	All	0.767	1.000	.015	5	view →
GBM	OS	Tertile	All	0.757	0.956	.011	2	view →
CCRCC	OS	Quartile	All	0.744	1.000	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GBE1–PDAC (OS)

Open the PDAC breakdown →