GBE1

Across TCGA pan-cancer cohorts, GBE1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of GBE1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GBE1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types GBE1 is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, LSCC, and CCRCC are the cancer types where GBE1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GBE1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−0.428	<.001	8	view →
LSCC	Male	All	−0.316	<.001	8	view →
CCRCC	All	II,III,IV	+0.287	<.001	8	view →
COAD	All	All	−0.112	.001	6	view →
LUAD	All	All	−0.093	.001	5	view →
OV	All	All	−0.330	.045	2	view →
PDAC	All	IV	+0.867	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

GBE1–HNSC

Open the HNSC breakdown →