GBE1

Across TCGA patient cohorts, GBE1 mutation is significantly associated with the RNA expression of many other genes, with 2,088 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBE1-associated genes across cancer lineages are CTLA4, RAD51, and MSANTD3. Each is linked with GBE1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GBE1-to-partner and partner-to-GBE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTLA4 grouped by GBE1-low versus GBE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBE1→partner) and Y-score (partner→GBE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CTLA4 →	+0.652	+2.364	.001	<.001	3	3
UCEC	RAD51 →	+0.654	+2.425	<.001	.001	3	3
UCEC	MSANTD3 →	+0.486	+2.010	<.001	<.001	3	3
UCEC	TIPIN →	+0.383	+2.272	.002	.001	3	3
UCEC	ITGAE →	+0.376	+1.716	<.001	.004	3	3
UCEC	LAG3 →	+0.983	+2.321	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,088 associations by consensus.

CTLA4 by GBE1 expression — UCEC

Explore this box plot interactively →