GBE1

Across TCGA patient cohorts, GBE1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBE1-associated genes across cancer lineages are PCNA, ATM, and Caspase-7-cleavedD198. Each is linked with GBE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBE1-to-partner and partner-to-GBE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by GBE1-low versus GBE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBE1→partner) and Y-score (partner→GBE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.192	+2.700	.010	.005	3	2
UCEC	ATM →	-0.392	-1.440	.012	.024	3	2
UCEC	Caspase-7-cleavedD198 →	+0.584	+2.827	.004	.001	3	2
UCEC	Cyclin-B1 →	+0.476	+2.115	.014	.017	3	2
COAD	LKB1 →	+0.178	+2.815	.001	.036	3	1
UCEC	EGFR_pY1068 →	-0.186	-1.736	.032	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PCNA by GBE1 expression — UCEC

Explore this box plot interactively →