GBA2

Across TCGA patient cohorts, GBA2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,399 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GBA2-associated genes across cancer lineages are RGP1, NPM3, and BAG1. Each is linked with GBA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GBA2-to-partner and partner-to-GBA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GBA2 versus RGP1 in PDAC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBA2→partner) and Y-score (partner→GBA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RGP1 →	+0.627	+0.299	.007	.007	3	4
LSCC	NPM3 →	-0.558	-0.221	<.001	<.001	3	4
COAD	BAG1 →	+0.666	+0.425	.003	.008	2	4
CCRCC	NDUFS1 →	+0.464	+0.264	<.001	.001	3	3
OV	CHMP5 →	+0.615	+0.466	.004	.009	3	3
UCEC	WASHC5 →	-0.377	-0.114	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,399 associations by consensus.

GBA2 vs RGP1 — PDAC

Explore this scatter interactively →