GBA2

Across TCGA cell cohorts, GBA2 mutation is significantly associated with the RNA expression of many other genes, with 97 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GBA2-associated genes across cancer lineages are IFNG, WFDC12, and TPD52L3. Each is linked with GBA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBA2-to-partner and partner-to-GBA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNG grouped by GBA2-low versus GBA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBA2→partner) and Y-score (partner→GBA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IFNG →	+0.225	+4.152	<.001	.009	3	1
BLOOD_Leukemia	WFDC12 →	+0.249	+4.874	<.001	.002	3	1
BLOOD_Leukemia	TPD52L3 →	+0.014	+4.539	<.001	.007	3	1
BLOOD_Leukemia	DEFB4A →	+0.123	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	KRTAP17-1 →	+0.680	+5.060	.008	.001	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.062	+4.539	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

IFNG by GBA2 expression — BLOOD_Leukemia

Explore this box plot interactively →