GBA

Across TCGA patient cohorts, GBA protein abundance is significantly associated with the RNA expression of many other genes, with 10,629 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GBA-associated genes across cancer lineages are SCARB2, RPS10P7, and SLC50A1. Each is linked with GBA in more than 4 cancer types. Because this analysis shows association rather than direction, both GBA-to-partner and partner-to-GBA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GBA versus SCARB2 in UCEC, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBA→partner) and Y-score (partner→GBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCARB2 →	+0.610	+0.449	<.001	<.001	3	5
UCEC	RPS10P7 →	+0.549	+0.310	.001	<.001	3	5
LUAD	SLC50A1 →	+0.665	+0.316	<.001	<.001	3	5
UCEC	DENND1B →	+0.608	+0.307	<.001	<.001	3	4
BRCA	DICER1 →	-0.813	-0.320	<.001	<.001	3	4
GBM	ZC3H14 →	-0.351	-0.355	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,629 associations by consensus.

GBA vs SCARB2 — UCEC

Explore this scatter interactively →