GBA

Across TCGA patient cohorts, GBA mutation is significantly associated with the RNA expression of many other genes, with 606 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBA-associated genes across cancer lineages are RN7SL210P, SERPINA13P, and OR1A2. Each is linked with GBA in more than 1 cancer types. Because this analysis shows association rather than direction, both GBA-to-partner and partner-to-GBA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL210P grouped by GBA-low versus GBA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBA→partner) and Y-score (partner→GBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL210P →	+0.110	+3.140	<.001	.008	3	2
BLCA	SERPINA13P →	+0.041	+4.177	.002	.002	3	2
LUAD	OR1A2 →	+0.035	+5.197	<.001	.003	3	2
LUAD	RNU6-679P →	+0.561	+4.481	.002	.009	3	2
UCEC	SLC35F6 →	+0.468	+3.362	.001	.005	3	2
UCEC	YPEL5P3 →	+0.089	+2.613	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 606 associations by consensus.

RN7SL210P by GBA expression — SKCM

Explore this box plot interactively →