GBA

Across TCGA patient cohorts, GBA mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBA-associated genes across cancer lineages are MSH2, eEF2, and MEK1. Each is linked with GBA in more than 1 cancer types. Because this analysis shows association rather than direction, both GBA-to-partner and partner-to-GBA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by GBA-low versus GBA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBA→partner) and Y-score (partner→GBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.270	-2.973	.009	.035	3	2
UCEC	eEF2 →	+0.432	+3.169	.007	.018	3	1
UCEC	MEK1 →	+0.481	+3.807	.003	<.001	3	1
UCEC	Notch1 →	+0.161	+2.000	.011	.032	3	1
UCEC	p62 Lck ligand →	+0.479	+2.700	.001	.006	3	1
UCEC	Rictor_pT1135 →	-0.119	-2.700	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MSH2 by GBA expression — UCEC

Explore this box plot interactively →