GBA

Across TCGA cell cohorts, GBA mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible GBA-associated genes across cancer lineages are ZSCAN1, PNLIPRP1, and C3orf85. Each is linked with GBA in more than 1 cancer types. Because this analysis shows association rather than direction, both GBA-to-partner and partner-to-GBA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZSCAN1 grouped by GBA-low versus GBA-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBA→partner) and Y-score (partner→GBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	PNLIPRP1 →	+0.035	+5.000	<.001	.006	3	1
PANCREAS	C3orf85 →	+0.178	+5.000	<.001	.006	3	1
PANCREAS	MYH4 →	+0.026	+5.000	<.001	.006	3	1
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	1
LUNG_SCLC	OR2M2 →	+0.118	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ZSCAN1 by GBA expression — PANCREAS

Explore this box plot interactively →