GATM

Across TCGA patient cohorts, GATM mutation is significantly associated with the RNA expression of many other genes, with 2,321 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GATM-associated genes across cancer lineages are HSPE1-MOB4, SSRP1, and PPP2R5E. Each is linked with GATM in more than 1 cancer types. Because this analysis shows association rather than direction, both GATM-to-partner and partner-to-GATM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPE1-MOB4 grouped by GATM-low versus GATM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATM→partner) and Y-score (partner→GATM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPE1-MOB4 →	+0.143	+1.992	.001	.003	3	2
UCEC	SSRP1 →	+0.516	+3.513	.002	.002	3	2
UCEC	PPP2R5E →	+0.415	+3.191	.007	.009	3	2
UCEC	ZC3H18 →	+0.534	+2.280	<.001	.001	3	2
UCEC	GART →	+0.510	+1.858	.004	.005	3	2
UCEC	NAE1 →	+0.625	+3.818	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,321 associations by consensus.

HSPE1-MOB4 by GATM expression — UCEC

Explore this box plot interactively →