GATD1

Across TCGA patient cohorts, GATD1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GATD1-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and Fibronectin. Each is linked with GATD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GATD1-to-partner and partner-to-GATD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GATD1-low versus GATD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATD1→partner) and Y-score (partner→GATD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.289	-3.584	.017	.002	3	1
UCEC	A-Raf_pS299 →	-0.243	-3.321	<.001	.010	3	1
UCEC	Fibronectin →	-0.327	-2.312	.040	.034	3	1
UCEC	Heregulin →	-0.165	-2.321	.005	.034	3	1
UCEC	INPP4B →	-0.362	-3.169	.020	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.226	+2.472	.023	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by GATD1 expression — UCEC

Explore this box plot interactively →