GATA6

Across TCGA pan-cancer cohorts, GATA6 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GATA6 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GATA6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GATA6 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where GATA6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.690	0.265	.003	13	view →
LUAD	DFS	Median	III,IV	0.922	0.409	.024	9	view →
LSCC	DFS	Quartile	All	0.343	0.976	.024	7	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GATA6–PDAC (DFS)

Open the PDAC breakdown →