GATA6

Across TCGA patient cohorts, GATA6 mutation is significantly associated with the RNA expression of many other genes, with 1,831 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GATA6-associated genes across cancer lineages are RNA5SP414, RNA5SP411, and RN7SL314P. Each is linked with GATA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GATA6-to-partner and partner-to-GATA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by GATA6-low versus GATA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATA6→partner) and Y-score (partner→GATA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.570	+2.603	<.001	<.001	3	2
UCEC	RNA5SP411 →	+0.952	+2.071	.001	.003	3	2
LIHC	RN7SL314P →	+0.108	+4.878	<.001	.005	3	2
LUSC	RNU6-821P →	+0.700	+3.748	<.001	.008	3	2
LUSC	RNA5SP419 →	+0.822	+5.517	<.001	.001	3	2
LUSC	RNA5SP418 →	+0.679	+4.393	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,831 associations by consensus.

RNA5SP414 by GATA6 expression — UCEC

Explore this box plot interactively →