GATA6

Across TCGA cell cohorts, GATA6 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GATA6-associated genes across cancer lineages are TRIM48, SPANXN4, and C1orf141. Each is linked with GATA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GATA6-to-partner and partner-to-GATA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM48 grouped by GATA6-low versus GATA6-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATA6→partner) and Y-score (partner→GATA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TRIM48 →	+0.310	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SPANXN4 →	+0.156	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf141 →	+0.023	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR2A25 →	+0.030	+4.807	<.001	.006	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TAS2R41 →	+0.028	+3.345	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

TRIM48 by GATA6 expression — BLOOD_Myeloma

Explore this box plot interactively →