GATA4

Across TCGA pan-cancer cohorts, GATA4 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated GATA4 data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher GATA4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GATA4 expression acts as an unfavorable survival marker.

ACC, LIHC, and STAD are the cancer types where GATA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
LIHC	OS	Median	All	0.051	0.783	<.001	36	view →
STAD	OS	Median	All	0.003	0.667	<.001	24	view →
LUSC	DFS	Median	All	0.010	0.792	<.001	24	view →
ESCA	OS	Median	All	0.022	0.701	<.001	12	view →
GBM	OS	Median	All	0.089	0.413	.015	6	view →
PRAD	DFS	Median	All	0.617	0.886	.027	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	III,IV	0.046	0.648	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

GATA4–ACC (DFS)

Open the ACC breakdown →