GATA2

Across TCGA patient cohorts, GATA2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GATA2-associated genes across cancer lineages are 14-3-3_beta, Rab25, and Shc_pY317. Each is linked with GATA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GATA2-to-partner and partner-to-GATA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by GATA2-low versus GATA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATA2→partner) and Y-score (partner→GATA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.128	-2.973	.008	.035	3	2
UCEC	Rab25 →	-0.469	-2.459	.003	.020	3	2
UCEC	Shc_pY317 →	-0.267	-2.459	<.001	.018	3	2
SKCM	Rb_pS807_S811 →	+0.624	+2.321	.003	.035	3	1
UCEC	A-Raf_pS299 →	-0.224	-3.169	<.001	.019	3	1
UCEC	GATA6 →	-0.179	-2.452	.016	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

14-3-3_beta by GATA2 expression — UCEC

Explore this box plot interactively →