GATA2

Across TCGA cell cohorts, GATA2 mutation is significantly associated with the RNA expression of many other genes, with 307 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GATA2-associated genes across cancer lineages are CA2, ARHGEF10, and TBC1D12. Each is linked with GATA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GATA2-to-partner and partner-to-GATA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CA2 grouped by GATA2-low versus GATA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATA2→partner) and Y-score (partner→GATA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CA2 →	+2.086	+3.502	<.001	.001	3	1
LARGE_INTESTINE	ARHGEF10 →	+1.287	+3.502	.002	.001	3	1
LARGE_INTESTINE	TBC1D12 →	+0.988	+3.502	<.001	.001	3	1
LARGE_INTESTINE	BLMH →	+0.930	+3.588	.001	<.001	3	1
LARGE_INTESTINE	BAG2 →	+0.928	+3.169	.004	.009	3	1
LARGE_INTESTINE	RAB23 →	+0.663	+3.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 307 associations by consensus.

CA2 by GATA2 expression — LARGE_INTESTINE

Explore this box plot interactively →