GASK1B

Across TCGA pan-cancer cohorts, GASK1B Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated GASK1B data layer compared with 29 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher GASK1B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GASK1B expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

CESC, LIHC, and SCLC are the cancer types where GASK1B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.053	0.786	<.001	30	view →
LIHC	OS	Median	II,III,IV	0.093	0.716	<.001	18	view →
SCLC	DFS	Median	All	0.228	0.635	.009	15	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
ACC	DFS	Median	All	0.195	0.748	.003	9	view →
LUAD	OS	Median	All	0.378	0.688	.010	9	view →
STAD	OS	Median	IV	0.001	0.544	<.001	6	view →
SKCM	DFS	Median	II,III,IV	0.238	0.711	.007	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
BLCA	DFS	Median	III,IV	0.866	0.264	.014	4	view →
COAD	DFS	Median	II,III,IV	0.482	0.757	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

GASK1B–CESC (DFS)

Open the CESC breakdown →