GASK1B

Across TCGA patient cohorts, GASK1B mutation is significantly associated with the RNA expression of many other genes, with 1,761 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GASK1B-associated genes across cancer lineages are PAQR8, MIR6868, and LEPROTL1. Each is linked with GASK1B in more than 2 cancer types. Because this analysis shows association rather than direction, both GASK1B-to-partner and partner-to-GASK1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAQR8 grouped by GASK1B-low versus GASK1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GASK1B→partner) and Y-score (partner→GASK1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAQR8 →	-0.560	-2.523	.002	<.001	3	3
LUSC	MIR6868 →	+0.427	+4.993	<.001	.003	3	3
UCEC	LEPROTL1 →	+0.333	+2.617	.006	.005	3	3
UCEC	MRPS7 →	+0.387	+2.742	.002	.002	3	3
UCEC	BTBD10 →	+0.398	+2.147	.004	.009	3	2
UCEC	ALDOA →	+0.523	+2.523	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,761 associations by consensus.

PAQR8 by GASK1B expression — UCEC

Explore this box plot interactively →