GASK1A

Across TCGA patient cohorts, GASK1A mutation is significantly associated with the RNA expression of many other genes, with 3,249 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GASK1A-associated genes across cancer lineages are TRAJ12, TRDV3, and SNORA59B. Each is linked with GASK1A in more than 1 cancer types. Because this analysis shows association rather than direction, both GASK1A-to-partner and partner-to-GASK1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ12 grouped by GASK1A-low versus GASK1A-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GASK1A→partner) and Y-score (partner→GASK1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	TRAJ12 →	+0.567	+3.023	<.001	.008	3	2
UCEC	TRDV3 →	+0.311	+1.772	<.001	.004	3	2
CESC	SNORA59B →	+0.075	+3.206	<.001	.005	3	2
UCEC	FAM219B →	+0.462	+2.807	.001	.003	3	1
UCEC	MSC →	+0.684	+3.470	.007	.002	3	1
UCEC	PFAS →	+0.534	+3.732	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,249 associations by consensus.

TRAJ12 by GASK1A expression — CESC

Explore this box plot interactively →