GASK1A

Across TCGA patient cohorts, GASK1A mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GASK1A-associated genes across cancer lineages are PCNA, ATM, and 14-3-3_beta. Each is linked with GASK1A in more than 1 cancer types. Because this analysis shows association rather than direction, both GASK1A-to-partner and partner-to-GASK1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by GASK1A-low versus GASK1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GASK1A→partner) and Y-score (partner→GASK1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.201	+1.874	.020	.049	3	2
UCEC	ATM →	-0.449	-3.156	.013	.018	3	2
UCEC	14-3-3_beta →	-0.105	-1.893	.009	.016	3	1
UCEC	eEF2 →	+0.385	+1.906	.007	.016	3	1
UCEC	eIF4E →	+0.170	+3.013	.045	.018	3	1
UCEC	A-Raf_pS299 →	-0.183	-3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PCNA by GASK1A expression — UCEC

Explore this box plot interactively →