GAS8

Across TCGA pan-cancer cohorts, GAS8 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GAS8 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GAS8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GAS8 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

LSCC, GBM, and LUAD are the cancer types where GAS8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.836	1.000	.001	21	view →
GBM	DFS	Quartile	All	0.727	0.209	.006	14	view →
LUAD	OS	Tertile	II,III,IV	0.718	0.326	.003	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GAS8–LSCC (DFS)

Open the LSCC breakdown →