GAS8

Across TCGA patient cohorts, GAS8 mutation is significantly associated with the RNA expression of many other genes, with 4,310 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAS8-associated genes across cancer lineages are COX15, CENPU, and CD8A. Each is linked with GAS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAS8-to-partner and partner-to-GAS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX15 grouped by GAS8-low versus GAS8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAS8→partner) and Y-score (partner→GAS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX15 →	+0.434	+1.947	<.001	<.001	3	2
UCEC	CENPU →	+0.740	+2.568	<.001	<.001	3	2
UCEC	CD8A →	+1.120	+2.557	<.001	<.001	3	2
UCEC	NEIL2 →	+0.509	+2.436	<.001	.001	3	2
UCEC	GBP5 →	+1.001	+2.546	<.001	<.001	3	2
UCEC	BUB3 →	+0.437	+3.075	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,310 associations by consensus.

COX15 by GAS8 expression — UCEC

Explore this box plot interactively →