GAS8

Across TCGA patient cohorts, GAS8 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAS8-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and A-Raf_pS299. Each is linked with GAS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAS8-to-partner and partner-to-GAS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by GAS8-low versus GAS8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAS8→partner) and Y-score (partner→GAS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.400	+2.502	.001	.001	3	2
COAD	Caspase-7-cleavedD198 →	+1.405	+2.824	<.001	.034	3	2
UCEC	A-Raf_pS299 →	-0.140	-2.222	<.001	.010	3	2
UCEC	PR →	-0.246	-2.807	.004	.003	3	2
UCEC	Rictor_pT1135 →	-0.091	-2.000	.010	.030	3	2
UCEC	TFRC →	+0.599	+3.807	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

MEK1 by GAS8 expression — UCEC

Explore this box plot interactively →