GAS8

Across TCGA cell cohorts, GAS8 mutation is significantly associated with the mutation status of many other genes, with 1,713 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GAS8-associated genes across cancer lineages are GREB1, LAMA4, and PRKCG. Each is linked with GAS8 in more than 3 cancer types. Because this analysis shows association rather than direction, both GAS8-to-partner and partner-to-GAS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GREB1 grouped by GAS8-low versus GAS8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAS8→partner) and Y-score (partner→GAS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GREB1 →	+2.422	+4.050	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	LAMA4 →	+4.392	+4.954	.008	.008	1	4
PANCREAS	PRKCG →	+5.115	+5.115	.005	.005	1	3
PANCREAS	EZR →	+5.115	+5.115	.005	.005	1	3
PANCREAS	COL3A1 →	+5.115	+5.115	.005	.005	1	3
LUNG_NSCLC_LUAD	DRP2 →	+3.584	+4.063	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,713 associations by consensus.

GREB1 by GAS8 expression — LARGE_INTESTINE

Explore this box plot interactively →