Across TCGA pan-cancer cohorts, GAS8-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GAS8-AS1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher GAS8-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GAS8-AS1 expression acts as an unfavorable survival marker, although some lineages such as LAML and SCLC show a favorable association.

LGG, UVM, and DLBC are the cancer types where GAS8-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.662	0.806	<.001	52	view →
UVM	DFS	Median	III,IV	0.208	0.740	.006	41	view →
DLBC	DFS	Quartile	All	0.466	0.953	.003	31	view →
CHOL	DFS	Median	II,III,IV	0.129	0.579	.001	27	view →
CESC	DFS	Quartile	All	0.718	0.865	.005	22	view →
MESO	OS	Median	II,III,IV	0.298	0.748	.004	21	view →
LAML	DFS	Median	All	0.645	0.490	.034	20	view →
THCA	DFS	Tertile	III,IV	0.830	0.960	.010	19	view →
HNSC	OS	Median	III,IV	0.222	0.415	.010	17	view →
SCLC	DFS	Median	II,III,IV	0.759	0.264	.023	16	view →
SARC	OS	Median	All	0.934	0.781	.002	14	view →
BRCA	DFS	Quartile	III,IV	0.876	0.700	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

Exploration

Same gene, other analysis: GAS8-AS1 tumor-vs-normal RNA expression · all GAS8-AS1 data types