GAS7

Across TCGA pan-cancer cohorts, GAS7 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated GAS7 data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GAS7 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated GAS7 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, LIHC, and SKCM are the cancer types where GAS7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.937	0.302	.007	32	view →
LIHC	OS	Median	All	0.119	0.704	.007	18	view →
SKCM	OS	Median	III,IV	0.179	0.814	<.001	18	view →
STAD	DFS	Median	All	1.000	0.381	.025	13	view →
SARC	DFS	Median	All	0.086	0.611	<.001	12	view →
KIRC	OS	Median	All	0.167	0.655	.038	12	view →
LAML	DFS	Median	All	0.140	0.582	.020	12	view →
LUAD	OS	Median	II,III,IV	0.165	0.681	<.001	6	view →
LGG	DFS	Median	All	0.230	0.753	.005	6	view →
ESCA	DFS	Median	III,IV	0.148	0.454	.002	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SCLC	DFS	Median	III,IV	1.000	0.197	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

GAS7–UCEC (DFS)

Open the UCEC breakdown →