GAS7

Across TCGA patient cohorts, GAS7 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAS7-associated genes across cancer lineages are Annexin-1, Caspase-7-cleavedD198, and ERK2. Each is linked with GAS7 in more than 2 cancer types. Because this analysis shows association rather than direction, both GAS7-to-partner and partner-to-GAS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by GAS7-low versus GAS7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAS7→partner) and Y-score (partner→GAS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.538	+2.926	.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.451	+1.807	.021	.024	3	3
UCEC	ERK2 →	+0.171	+2.000	.006	.009	3	2
UCEC	MEK1 →	+0.457	+3.807	<.001	<.001	3	2
UCEC	Rictor_pT1135 →	-0.078	-1.652	.021	.006	3	2
UCEC	ATM →	-0.662	-2.263	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Annexin-1 by GAS7 expression — UCEC

Explore this box plot interactively →