GAS6

Across TCGA pan-cancer cohorts, GAS6 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GAS6 data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GAS6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GAS6 expression acts as an unfavorable survival marker.

COAD, CCRCC, and LSCC are the cancer types where GAS6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.683	1.000	.038	12	view →
CCRCC	DFS	Tertile	II,III,IV	0.198	0.887	.024	12	view →
LSCC	OS	Median	II,III,IV	0.904	1.000	.018	12	view →
PDAC	OS	Median	II,III,IV	0.268	0.507	.016	4	view →
HNSC	DFS	Quartile	II,III,IV	0.578	0.849	.014	4	view →
UCEC	OS	Tertile	II,III,IV	0.677	1.000	.042	4	view →
LUAD	DFS	Median	III,IV	0.348	0.709	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GAS6–COAD (DFS)

Open the COAD breakdown →