GAS6

Across TCGA patient cohorts, GAS6 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAS6-associated genes across cancer lineages are eIF4E, ATM, and EGFR_pY1068. Each is linked with GAS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAS6-to-partner and partner-to-GAS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GAS6-low versus GAS6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAS6→partner) and Y-score (partner→GAS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.216	+3.013	<.001	<.001	3	2
UCEC	ATM →	-0.384	-1.986	.006	.008	3	2
UCEC	EGFR_pY1068 →	-0.170	-1.415	.029	.010	3	1
UCEC	JNK2 →	+0.186	+1.704	.002	.011	3	1
UCEC	MEK1 →	+0.449	+2.169	<.001	<.001	3	1
UCEC	Notch1 →	+0.102	+1.643	.019	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4E by GAS6 expression — UCEC

Explore this box plot interactively →