GAS6

Across TCGA cell cohorts, GAS6 mutation is significantly associated with the RNA expression of many other genes, with 293 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GAS6-associated genes across cancer lineages are SPATA19, DEFA3, and NOBOX. Each is linked with GAS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAS6-to-partner and partner-to-GAS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA19 grouped by GAS6-low versus GAS6-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAS6→partner) and Y-score (partner→GAS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SPATA19 →	+0.036	+5.169	<.001	.004	3	1
BONE	DEFA3 →	+0.090	+5.169	<.001	.004	3	1
URINARY_TRACT	NOBOX →	+0.020	+5.044	<.001	<.001	3	1
URINARY_TRACT	NPHS2 →	+0.187	+5.044	<.001	<.001	3	1
URINARY_TRACT	CLEC14A →	+0.013	+4.217	.007	.005	3	1
URINARY_TRACT	TMEM252 →	+0.637	+4.217	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 293 associations by consensus.

SPATA19 by GAS6 expression — BONE

Explore this box plot interactively →