GAS2L3

Across TCGA patient cohorts, GAS2L3 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAS2L3-associated genes across cancer lineages are Ku80, Notch1, and VHL. Each is linked with GAS2L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAS2L3-to-partner and partner-to-GAS2L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by GAS2L3-low versus GAS2L3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAS2L3→partner) and Y-score (partner→GAS2L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.215	+2.598	.017	<.001	3	2
UCEC	Notch1 →	+0.199	+2.128	<.001	.009	3	2
UCEC	VHL →	-0.543	-2.087	.037	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.674	+2.479	.003	.010	3	2
UCEC	Cyclin-B1 →	+0.446	+2.999	.038	.035	3	2
UCEC	GSK-3_pS9 →	-0.330	-1.700	.033	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Ku80 by GAS2L3 expression — UCEC

Explore this box plot interactively →