GAS2L3

Across TCGA cell cohorts, GAS2L3 mutation is significantly associated with the RNA expression of many other genes, with 144 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GAS2L3-associated genes across cancer lineages are SEL1L2, APOC4, and DMRTC2. Each is linked with GAS2L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAS2L3-to-partner and partner-to-GAS2L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEL1L2 grouped by GAS2L3-low versus GAS2L3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAS2L3→partner) and Y-score (partner→GAS2L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SEL1L2 →	+0.030	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	APOC4 →	+0.066	+6.266	<.001	<.001	3	1
BLOOD_Lymphoma	DMRTC2 →	+0.013	+5.643	<.001	.002	3	1
SKIN	CYP4F8 →	+0.016	+3.217	<.001	.006	3	1
LARGE_INTESTINE	FGF8 →	+0.334	+3.212	.001	.006	3	1
LARGE_INTESTINE	C1QBP →	+0.736	+3.299	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 144 associations by consensus.

SEL1L2 by GAS2L3 expression — URINARY_TRACT

Explore this box plot interactively →