GAS2L2

Across TCGA patient cohorts, GAS2L2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAS2L2-associated genes across cancer lineages are Chk2_pT68, ATM, and Caspase-7-cleavedD198. Each is linked with GAS2L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GAS2L2-to-partner and partner-to-GAS2L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2_pT68 grouped by GAS2L2-low versus GAS2L2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAS2L2→partner) and Y-score (partner→GAS2L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk2_pT68 →	+0.125	+1.515	.011	.016	3	3
UCEC	ATM →	-0.595	-2.807	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.558	+2.135	.009	.010	3	3
UCEC	4E-BP1 →	+0.276	+3.584	.004	.002	3	3
SKCM	Stathmin →	+0.130	+1.700	.021	.038	3	2
UCEC	eIF4E →	+0.191	+2.335	.011	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Chk2_pT68 by GAS2L2 expression — SKCM

Explore this box plot interactively →