GAS2

Across TCGA pan-cancer cohorts, GAS2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GAS2 data layer compared with 29 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GAS2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GAS2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where GAS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.985	0.674	.039	4	view →
UCEC	DFS	Tertile	All	0.939	0.629	.040	4	view →
HNSC	OS	Median	IV	0.634	1.000	.038	4	view →
PDAC	OS	Median	All	0.931	0.721	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GAS2–CCRCC (OS)

Open the CCRCC breakdown →