GAS2

Across TCGA patient cohorts, GAS2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAS2-associated genes across cancer lineages are Notch1, Caspase-8, and C-Raf. Each is linked with GAS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAS2-to-partner and partner-to-GAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by GAS2-low versus GAS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAS2→partner) and Y-score (partner→GAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.139	+1.594	.008	.042	3	2
UCEC	Caspase-8 →	-0.242	-2.780	.010	.003	3	2
UCEC	C-Raf →	+0.131	+2.700	.014	.006	3	2
UCEC	Di-Ras3 →	-0.159	-2.169	.004	.003	3	2
UCEC	14-3-3_beta →	-0.105	-3.295	.005	.009	3	1
UCEC	EGFR_pY1068 →	-0.188	-2.459	.046	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Notch1 by GAS2 expression — UCEC

Explore this box plot interactively →