GAS1

Across TCGA pan-cancer cohorts, GAS1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GAS1 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GAS1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GAS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

PDAC, LUAD, and GBM are the cancer types where GAS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.740	1.000	.022	4	view →
LUAD	DFS	Median	II,III,IV	0.748	0.207	.023	4	view →
GBM	OS	Tertile	All	0.664	0.314	.021	3	view →
HNSC	OS	Tertile	IV	0.444	0.843	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GAS1–PDAC (OS)

Open the PDAC breakdown →