GAS1

Across TCGA patient cohorts, GAS1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible GAS1-associated genes across cancer lineages are OR5L2, AARS1P1, and OR4X7P. Each is linked with GAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAS1-to-partner and partner-to-GAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5L2 grouped by GAS1-low versus GAS1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAS1→partner) and Y-score (partner→GAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR5L2 →	+0.034	+7.930	<.001	.008	3	1
LUAD	AARS1P1 →	+0.069	+7.930	<.001	.008	3	1
LUAD	OR4X7P →	+0.239	+7.930	<.001	.008	3	1
LUAD	MIR4695 →	+0.348	+7.930	<.001	.008	3	1
LUAD	MIR4289 →	+0.527	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR5L2 by GAS1 expression — LUAD

Explore this box plot interactively →