GARS1

Across TCGA patient cohorts, GARS1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GARS1-associated genes across cancer lineages are Lck, 14-3-3_beta, and EGFR_pY1068. Each is linked with GARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GARS1-to-partner and partner-to-GARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by GARS1-low versus GARS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GARS1→partner) and Y-score (partner→GARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.162	+2.000	.028	.030	3	2
UCEC	14-3-3_beta →	-0.088	-2.295	.017	.033	3	1
UCEC	EGFR_pY1068 →	-0.201	-2.459	.029	.018	3	1
UCEC	A-Raf_pS299 →	-0.112	-2.115	.010	.017	3	1
UCEC	ERK2 →	+0.201	+2.736	.004	<.001	3	1
UCEC	JNK2 →	+0.188	+1.502	.009	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Lck by GARS1 expression — UCEC

Explore this box plot interactively →