GARRE1

Across TCGA patient cohorts, GARRE1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GARRE1-associated genes across cancer lineages are Ku80, p90 RSK, and Rad50. Each is linked with GARRE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GARRE1-to-partner and partner-to-GARRE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by GARRE1-low versus GARRE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GARRE1→partner) and Y-score (partner→GARRE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.212	+2.009	.002	.001	3	3
UCEC	p90 RSK →	+0.149	+1.906	.010	.014	3	2
UCEC	Rad50 →	-0.163	-1.530	.025	.004	3	2
UCEC	STAT3_pY705 →	-0.361	-1.706	<.001	.003	3	2
UCEC	ASNS →	+0.239	+1.125	.028	.033	3	2
UCEC	Chk2_pT68 →	-0.114	-1.492	.042	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Ku80 by GARRE1 expression — UCEC

Explore this box plot interactively →