GARNL3

Across TCGA pan-cancer cohorts, GARNL3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated GARNL3 data layer compared with 8 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher GARNL3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GARNL3 expression acts as an unfavorable survival marker, although some lineages such as BLCA and KIRC show a favorable association.

BLCA, KIRC, and HNSC are the cancer types where GARNL3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Quartile	II,III,IV	0.765	0.595	<.001	96	view →
KIRC	DFS	Median	All	0.735	0.538	<.001	93	view →
HNSC	OS	Quartile	All	0.507	0.326	<.001	74	view →
KIRP	DFS	Quartile	All	0.944	0.507	.002	25	view →
UCEC	DFS	Median	All	0.577	0.704	.023	18	view →
LIHC	OS	Median	II,III,IV	0.583	0.316	.018	18	view →
PAAD	DFS	Tertile	All	0.426	0.220	.008	17	view →
SKCM	DFS	Median	II,III,IV	0.800	0.617	.014	14	view →
LAML	DFS	Tertile	All	0.258	0.542	.007	14	view →
COAD	DFS	Quartile	All	0.273	0.647	.012	13	view →
ESCA	OS	Tertile	IV	0.219	0.916	.024	12	view →
OV	OS	Tertile	All	0.275	0.397	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GARNL3–BLCA (OS)

Open the BLCA breakdown →