GAREM2

Across TCGA patient cohorts, GAREM2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAREM2-associated genes across cancer lineages are Caspase-7-cleavedD198, Di-Ras3, and EGFR_pY1068. Each is linked with GAREM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAREM2-to-partner and partner-to-GAREM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GAREM2-low versus GAREM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAREM2→partner) and Y-score (partner→GAREM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.631	+3.321	.008	.009	3	2
UCEC	Di-Ras3 →	-0.171	-2.986	.004	.035	3	2
UCEC	EGFR_pY1068 →	-0.296	-2.321	.003	.033	3	1
UCEC	A-Raf_pS299 →	-0.204	-1.874	<.001	.049	3	1
UCEC	FoxM1 →	+0.216	+2.415	.037	.003	3	1
UCEC	JNK2 →	+0.253	+1.906	.001	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Caspase-7-cleavedD198 by GAREM2 expression — UCEC

Explore this box plot interactively →