GAREM2

Across TCGA cell cohorts, GAREM2 mutation is significantly associated with the RNA expression of many other genes, with 405 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GAREM2-associated genes across cancer lineages are C20orf85, CBY1, and DDHD1. Each is linked with GAREM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAREM2-to-partner and partner-to-GAREM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by GAREM2-low versus GAREM2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAREM2→partner) and Y-score (partner→GAREM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.056	+5.969	<.001	.001	3	1
LARGE_INTESTINE	CBY1 →	+0.916	+3.482	<.001	<.001	3	1
LARGE_INTESTINE	DDHD1 →	+0.750	+3.364	.002	.002	3	1
LARGE_INTESTINE	PLTP →	-1.939	-3.278	.005	.006	3	1
LARGE_INTESTINE	ACOT8 →	-0.749	-3.278	<.001	.006	3	1
LARGE_INTESTINE	ADNP2 →	+0.949	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 405 associations by consensus.

C20orf85 by GAREM2 expression — BLOOD_Leukemia

Explore this box plot interactively →