GAREM1

Across TCGA patient cohorts, GAREM1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAREM1-associated genes across cancer lineages are 14-3-3_beta, eIF4G, and MSH2. Each is linked with GAREM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAREM1-to-partner and partner-to-GAREM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by GAREM1-low versus GAREM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAREM1→partner) and Y-score (partner→GAREM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.066	-1.388	.026	.041	3	2
SKCM	eIF4G →	+0.374	+3.000	.030	.034	3	2
UCEC	MSH2 →	-0.273	-2.710	<.001	<.001	3	2
SKCM	RBM15 →	+0.391	+2.115	.020	.018	3	2
UCEC	STAT3_pY705 →	-0.343	-1.826	<.001	.001	3	2
UCEC	ATM →	-0.480	-1.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

14-3-3_beta by GAREM1 expression — UCEC

Explore this box plot interactively →