GAREM1

Across TCGA cell cohorts, GAREM1 mutation is significantly associated with the RNA expression of many other genes, with 381 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GAREM1-associated genes across cancer lineages are GP2, HPSE2, and ISX. Each is linked with GAREM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAREM1-to-partner and partner-to-GAREM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GP2 grouped by GAREM1-low versus GAREM1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAREM1→partner) and Y-score (partner→GAREM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GP2 →	+0.140	+3.273	<.001	.006	3	1
LUNG_NSCLC_LUAD	HPSE2 →	+0.254	+3.789	<.001	.004	3	1
LUNG_NSCLC_LUAD	ISX →	+0.516	+3.343	<.001	.005	3	1
LUNG_NSCLC_LUAD	HTR3E →	+0.065	+3.980	<.001	.002	3	1
SKIN	OR56B1 →	+0.044	+4.273	<.001	.006	3	1
SKIN	SCYGR10 →	+0.178	+4.684	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 381 associations by consensus.

GP2 by GAREM1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →